oon OON CHERN EIN
Dr.
Senior Lecturer

Address : Main Campus, USM Pulau Pinang

email chern.oon@usm.my

Biography


Dr Oon Chern Ein completed her BSc (1st Class Hons) in Biotechnology at Universiti Kebangsaan Malaysia before securing a scholarship from the Ministry of Higher Education Malaysia to further her doctorate studies in Medical Oncology in University of Oxford, United Kingdom. She then trained at Karolinska Institutet, Sweden as a postdoctoral fellow before returning to Malaysia to serve as a lecturer at Institute for Research in Molecular Medicine, Universiti Sains Malaysia. Chern is an active member of American Association for Cancer Research (AACR), a fellow of the Association of Union for International Cancer Control (AUF) and an ambassador for European Association for Cancer Research (EACR). She is also a member of the Young Scientists Network- Academy of Sciences Malaysia. In 2014, she won the Exiqon Young Scientist Award- South East Asia and was the sole recipient of the Ranjeet Bhagwan Singh Medical Research Trust Fund. Chern was selected by the Council for the Lindau Nobel Laureate Meetings to participate in the 65th Lindau Nobel Laureate Meeting in Germany in 2015. She continues to receive numerous awards for her work on novel molecular therapeutics in cancer including the prestigious L'Oreal-UNESCO for Women in Science National Fellowship in 2015 and the Union for International Cancer Control ICRETT Fellowship in 2016.

Google scholar link

Research Interest


Dr Oon's area of research includes understanding the molecular interactions between cancer cells and the tumour microenvironment which contribute to tumour progression and therapeutic failures. Her work focuses on dissecting the molecular mechanisms conferring to chemoresistance and exploring the benefits of novel agents towards the development of new molecular targeted therapies in cancer.

(Principal Investigator)
  1. Fundamental Studies On The Mechanism Of Action Of A Novel Sirtuin Inhibitor (BZD9L1) In Colorectal Cancer Cells- Towards The Elucidation Of A Novel Cancer Therapeutic Agent 
  2. In vitro and in vivo studies on the complementary effects of standardized ethanolic Orthosiphon stamineus extract on pancreatic cancer
  3. Clinical Relevance And The Functional Role Of Notch Components In Tumour Angiogenesis–Fundamental Studies Towards The Development Of Novel Molecular Targeted Therapy

(Co-researcher)

  1. Genomic Expression Profile Of Human Papilloma Virus (HPV) 16 And-Associated Pre-Cancerous Lesions And Cancer Of The Cervix
  2. Fundamental studies on the mechanism of action of Polyalthial longifoliapolyphenolics in HeLa cells through the regulations of miRNAs
  3. The Efficacy of Oral Versus Ophthalmic Preparations of Standardized Extract of Orthosiphon Stamineus for Adjunctive Management of Retinal Neovascularization Secondary to Proliferative Diabetic Retinopathy
  4. Biochemical Characterization of Sirtuin (1&6) and Amyloid Protein Pathway in Alzheimer's Cellular Model SHSY5Y 

Publications

1)                  Muhammad Asif, Armaghan Shafaei, Seyedeh Fatemeh  Jafari, Shazmin binti  Kithur Mohamed, Mohammed Oday Ezzat,  Aman Shah  Abdul Majid , Chern Ein  Oon,  Sven  H. Petersen, Koji  Kono, Amin Malik Shah  Abdul Majid. Isoledene, a natural sesquiterpene from Mesua ferrea Oleo-gum resin inhibits cell growth and induces apoptosis in human colorectal carcinoma cells through ROS-mediated mitochondrial pathway (In press, Toxicology Letters)

2)                  Muhammad, A., Shafaei, A., l Majid, A.S., Oon, C.E., Majid,A.M.A. Mesua ferrea stem bark extract induces apoptosis and inhibits metastasis in human colorectal carcinoma HCT 116 cells through modulation of multiple cell signalling pathways (In press, Chinese Journal of Natural Medicines)
3)                  Tabana YM, Hassan LE, Ahamed MB, Dahham SS, Iqbal MA, Saeed MA, Khan MS, Sandai D, Majid AS, Oon CE, Majid AM. Scopoletin, an active principle of Tree Tobacco (Nicotiana glauca) Inhibits Human Tumor Vascularization in Xenograft Models and Modulates ERK1, VEGF-A, and FGF-2 in Computer Model. Microvasc Res. 2016 Apr 28. pii: S0026-2862(16)30037-1. doi: 10.1016/j.mvr.2016.04.009. [Epub ahead of print] PMID:27133199]

4)                  Yeong, K.Y. and Oon, C.E.Sirtuin inhibitors: An overview from medicinal chemistry perspective. Anti-Cancer Agents in Medicinal Chemistry (2016), vol. 16(8) E-pub ahead of print
5)                  K.Y. Yeong , M.A. Ali, C.W. Ang, S.C. Tan , C.E. Oon, A. N. Shirazi, K. Parang.
Discovery of a potent and highly fluorescent sirtuin inhibitor.DOI: 10.1039/C5MD90057C, Med. Chem. Commun., 2015, 6, 2235-2235
6)                  Asif M, Iqbal MA, Hussein MA, Oon CE, Haque RA, Khadeer Ahamed MB, Abdul Majid AS, Abdul Majid AM. Human colon cancer targeted pro-apoptotic, anti-metastatic and cytostatic effects of binuclear Silver(I)-N-Heterocyclic carbene (NHC) complexes.Eur J Med Chem (2015) 25;108:177-187. doi: 10.1016/j.ejmech.2015.11.034. 

7)                  Kwan, Y.P., Saito, T, Ibrahim, D., Al-Hassan, F.M., Oon, C.E., Chen Y., Jothy, S.L., Kanwar, J,R,, Sasidharan, S. Evaluation of the cytotoxicity, cell-cycle arrest, and apoptotic induction by Euphorbia hirta in MCF-7 breast cancer cells. Pharm Biol (2015): 1-14.

8)                  Oon, C.E., Strell, C., Yeong, K.Y., Ostman, A., Prakash, J. SIRT1 inhibition in pancreatic cancer models; contrasting effects in vitro and in vivo. European Journal of Pharmacology (2015), vol (15)757:59-67.

9)                   Muhammad Asif; Ashwaq Hamid Salem Yehya; Majed Ahmed Al-Mansoub; Vageesh Revadigar; Mohammed Oday Ezzat; Mohamed B Khadeer Ahmed; Chern Ein Oon; Vikneswaran Murugaiyah; Aman Shah Abdul Majid; Amin Malik Shah Abdul Majid. Anticancer attributes of Illicium verum essential oils against colon cancer. South African Journal of Botany (2016), vol. 103 156–161.

10)               Soundararajan, V., Oon, C.E., Subramanion., L.J., Chen, Y., Kanwar., J.R., Sreenivasan, S. MicroRNA Pathways: an Emerging Role in Identification of Therapeutic Strategies. Current Gene Therapy (2014), vol 14(2):112-20.

11)               Hassan,L.E.A., Ahamed., M.B.K, Majid, A.S.A., Iqbal, M.A., Al-Suede, F.S.R.,Haque, R.A., Ismail, Z., Oon, C.E., Majid, A.M.S.H. Crystal Structure Elucidation and Anticancer Studies of (-)-Pseudosemiglabrin: A Flavanone Isolated from the Aerial Parts of Tephrosia apollinea. PLOS One (2014), vol. 9 (3): e90806.

12)               Subramanion., L. J., Oon, C.E., Sreenivasan, S. Natural Pro-oxidant: an alternative remedy to explore as novel cancer therapeutic agents.Asian Pac J Cancer Prev(2014), vol 15 (3): 1501.

13)               Nowroji, K., Soundararajan, V., Subramanion, L.J., Oon, C.E., Yeng, C., Jagat,R.K., Sreenivasan, S. MicroRNAs: Biogenesis, Roles for Carcinogenesis and as Potential Biomarkers for Cancer Diagnosis and PrognosisAsian Pac J Cancer Prev (2014), vol 15(18):7489-97.

14)               Lachumy, S.J., Oon, C.E., Deivanai, S., Saravanan, D., Vijayarathna, S., Choong, Y.S., Yeng,C., Latha, L.Y., Sreenivasan, S. Herbal remedies for combating lethalirradiation: a green anti-irradiation approach. Asian Pac J Cancer Prev (2013), vol 14(10):5553-65.

15)               Moad, A.I, Tengku Muhammad T.S.T., Oon, C.E., Tan, M.L. Rapamycin induces    apoptosis when autophagy is Inhibited in T-47D mammary cells and both processes are regulated by Phlda1. Cell Biochem Biophys (2013),vol. 66(3):567-87.

16)               Tan, M.L., Tan, H.K., Oon, C.E.Kuroyanagi, M., Muhammad, T.S.T.Identification of genes involved in the regulation of 14-deoxy-11, 12-didehydroandrographolide-induced toxicity in T-47D mammary cells.Food Chem Toxicol(2012), vol. 50(2):431-44.

17)               Li, J.L. Sainson, R.S., Oon, C.E., Turley, H., Leek, R., Sheldon, H., Bridges, E., Shi, W., Snell, C., Bowden, E.T., Wu, H., Chowdhury, P.S., Russell, A.J., Montgomery, C.P., Poulsom, R., Harris. A.L. DLL4-Notch signalling mediates tumour resistance to anti-VEGF therapy in vivo. Cancer Research (2011), vol. 71(18):6073-83.

18)               Oon, C.E. and Harris, A.L. New pathways and mechanisms regulating and responding to deltalike 4-Notch signalling in tumour angiogenesis.Biochem Soc Trans(2011), vol 39(6):1612-8.

19)               Bridges, E.*, Oon. C.E.*, Harris, A.L. Notch regulation of tumour angiogenesis. Future Oncology (2011), vol. 7(4): 569-88.    * Joint first authorship

20)               Sheldon, H., Heikamp, E., Turley, H., Dragovic, R., Thomas, P., Oon, C.E., Leek, R., Edelmann, M., Kessler, B., Sainson, R.C.A, Sargent, I., Li, J.L., Harris, A.L. New mechanism for notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes. Blood (2010), vol. 116(13):2385-94.